Lionheart Health and Rejuvant Partner for XPRIZE Healthspan Semi-Finals with Comprehensive Healthspan Platform

Lionheart Health, a regenerative health and longevity technology company, announced a strategic partnership with Rejuvant, developer of patented sustained-release Calcium alpha-ketoglutarate supplementation, as part of Lionheart Health's participation in the XPRIZE Healthspan Semi-Finals. Lionheart Health was selected as a top 40 semi-finalist out of more than 600 entries in spring 2025. Under the collaboration, Rejuvant's CaAKG supplement has been designated a mandatory core component of the Lionheart KLOTHO-UP™ Study and broader Lionheart Klotho Wellness Program, both central to Lionheart's XPRIZE Healthspan initiative.

The Lionheart KLOTHO-UP™ Study integrates Rejuvant's CaAKG supplementation within a multi-modal healthspan optimization framework designed to evaluate coordinated improvements across muscle, metabolic, immune, cardiovascular, and brain health domains. In addition to Rejuvant CaAKG, all study participants receive SNiP Nutrition™ personalized supplements customized based on genetic and biomarker profiles, targeted Klotho-focused supplementation, and Lionheart Health's BodStim™ bioelectric exercise platform delivering Klotho- and follistatin-elevating electrical muscle stimulation-enhanced exercise sessions. This integrated approach reflects Lionheart's belief that meaningful healthspan extension requires both lifestyle optimization and advanced biological technologies working in concert.

All enrollees in the KLOTHO-UP™ Study and Klotho Wellness Program undergo extensive testing and evaluation protocols at baseline, 3 months, 6 months, and 12 months, including a 461-biomarker comprehensive blood panel including klotho levels, AI-enhanced full-body MRI with targeted organ and tissue analysis, muscle health assessments, gut health and microbiome evaluation, breathing and sleep analysis, stress and inflammation profiling, blood sugar and metabolic regulation analysis, vascular and calcification assessment, joint health and mobility evaluation, sexual health assessment, vision and hearing evaluation, and brain health testing including cognition, memory, and mood metrics. This longitudinal design enables objective tracking of functional healthspan changes over time rather than reliance on single-endpoint or short-duration outcomes.

A spokesperson for Lionheart Health stated that Rejuvant's CaAKG platform represents one of the most rigorously studied nutritional interventions in the biological aging space, and by making CaAKG a mandatory core component of their XPRIZE Healthspan protocol, they are anchoring their program in validated metabolic biology while layering in advanced bioelectric, Klotho-focused, and personalized technologies. A representative from Rejuvant added that they are excited to partner with Lionheart Health in the XPRIZE Healthspan Semi-Finals, noting this collaboration allows CaAKG supplementation to be evaluated within one of the most comprehensive, biomarker-driven healthspan programs ever assembled. More information about the program is available at https://lionheartlongevity.com/treatment/klotho-wellness-program/.