Lionheart Health Launches Klotho-Up Study to Assess Structured Wellness Program's Impact on Aging Markers

Lionheart Health, Inc., a company focused on bioelectric regenerative medicine and healthspan optimization, announced that enrollment is beginning for its Lionheart Klotho-Up™ Study, a longitudinal program designed to assess whether a practical, structured wellness and bioelectric intervention program may help support key markers of healthy aging. The study is built around two core required program elements: daily Klotho-favoring meals, supplements, and beverages designed to support a biologically favorable environment for healthy aging, and BodStim™ Klotho-enhancing exercise performed two or three times per week for one hour per session. Participants may also choose to add from a broader menu of optional supportive therapies, which may include hyperbaric oxygen therapy, red light therapy, cold therapy, pulsed electromagnetic field (PEMF) therapy, organ-targeted bioelectric stimulation, and other wellness-supportive interventions depending on availability, candidacy, and site offerings.

Howard Leonhardt, Executive Chairman and co-CEO of Lionheart Health, stated that the company's goal is to make a Klotho-supportive lifestyle and bioelectric wellness program more structured, measurable, and accessible. He emphasized that many people want more than vague longevity advice, seeking a guided program, objective testing, and the opportunity to track whether their efforts, including technological interventions such as bioelectric controlled protein expressions, are improving meaningful indicators of muscle, cognitive, and immune health over time. All participants must complete a formal informed patient consent process and agree to required baseline and one-year follow-up assessments, which include muscle health evaluations like grip strength and gait speed, brain health assessments such as standardized cognitive testing, and immune health checks including gut intelligence testing and various biomarkers.

In addition, all participants must complete a 461 blood biomarker panel at baseline and again at one year, with optional testing at three and six months. An AI-enhanced MRI through CoreViva will also be available on an optional basis for deeper body composition insights. For selected candidates at certain outside the United States affiliated sites, biologic therapies may be available, requiring a separate, higher-risk informed patient consent and offered only where legally permissible and medically appropriate. Klotho is widely recognized as an important longevity-associated protein linked to multiple aspects of healthy aging, including muscle function, brain health, vascular and metabolic health, inflammation balance, and overall healthy aging biology, making this study significant for those aiming to maintain strength, mobility, energy, cognitive sharpness, and immune resilience with age.

Enrollment is opening on a limited basis for qualified participants at licensed clinics, with the study being a subsidized paid registry. Patients will pay $12.99 a day for health fresh Klotho-favoring meals delivered to their home or can choose to shop themselves following recipes to save costs, while the BodStim™ EMS suit can be leased for one year with an $890 down payment and monthly payments of $188. The 461 biomarker test costs $800 each for non-members and $463 for members, with Lionheart Health covering all muscle, brain, and immunity health test assessments at baseline and one year, while optional AI-enhanced MRI scans and additional testing will be covered by patients. This study supports Lionheart Health's participation in XPRIZE Healthspan, where the company was named a Top 40 Milestone 1 awardee semi-finalist from more than 600 registered teams worldwide, reflecting the strength of its proposed therapeutic approach and clinical testing strategy. The Lionheart Klotho-Up™ Study is intended for research, wellness, and health optimization purposes, with participation requiring informed consent and individual results varying, and it is not intended as medical advice or a claim of diagnosis, treatment, cure, or prevention of disease.