Lionheart Health Announces Enrollment Beginning for Lionheart Klotho-Up™ Study

Lionheart Health, Inc., a company focused on bioelectric regenerative medicine and healthspan optimization, today announced that enrollment is beginning for its Lionheart Klotho-Up™ Study, a longitudinal program designed to assess whether a practical, structured wellness and bioelectric intervention program may help support key markers of healthy aging.

The Lionheart Klotho-Up™ Study is built around two core required program elements:

Daily Klotho-favoring meals, supplements, and beverages designed to support a biologically favorable environment for healthy aging; and
BodStim™ Klotho-enhancing exercise performed two or three times per week for one hour per session.

Participants may also choose to add from a broader menu of optional supportive therapies, which may include hyperbaric oxygen therapy, red light therapy, cold therapy, pulsed electromagnetic field (PEMF) therapy, organ-targeted bioelectric stimulation, and other wellness-supportive interventions depending on availability, candidacy, and site offerings.

“Lionheart’s goal is to make a Klotho-supportive lifestyle and bioelectric wellness program more structured, measurable, and accessible,” said Howard Leonhardt, Executive Chairman and co-CEO of Lionheart Health. “We believe many people want more than vague longevity advice. They want a guided program, objective testing, and the opportunity to track whether their efforts, including technological interventions such as bioelectric controlled protein expressions, are improving meaningful indicators of muscle, cognitive, and immune health over time.”

All participants in the Lionheart Klotho-Up™ Study must complete a formal informed patient consent process and agree to required baseline and one-year follow-up assessments. Required core assessments include:

1. Muscle Health

Grip strength
Gait speed
6-minute walk test
Muscle mass assessment

2. Brain Health

Standardized cognitive testing
Memory testing
Mood assessment

3. Immune Health

Gut intelligence testing
Various immune and wellness-related biomarkers

In addition, all participants must complete a 461 blood biomarker panel at baseline and again at one year. Participants may also elect to add biomarker testing at 3 months and 6 months, and in some cases an additional test at approximately 4 weeks may be recommended to help optimize supplements and program adherence.

An AI-enhanced MRI through CoreViva will also be available on an optional basis for participants seeking deeper body composition and imaging-based insights.

For selected candidates at certain outside the United States (OUS) affiliated sites, biologic therapies may also be available. These therapies would require a separate, higher-risk informed patient consent and would only be offered where legally permissible, medically appropriate, and under the oversight of the applicable treating clinicians and site protocols.

Why Klotho Matters

Klotho is widely recognized as an important longevity-associated protein linked to multiple aspects of healthy aging. It has been associated with support for:

Healthy muscle function and physical resilience
Brain health, cognition, and neurological vitality
Vascular and metabolic health
Inflammation balance and cellular stress response
Overall healthy aging biology

Many individuals may wish to improve or support Klotho-related biology as part of a broader effort to maintain strength, mobility, energy, cognitive sharpness, and immune resilience with age.

The Lionheart Klotho-Up™ Study is intended to help participants and clinicians evaluate how a structured program of nutrition, supplementation, bioelectric exercise, and optional supportive therapies may correlate with measurable changes over time.

Enrollment is now opening on a limited basis for qualified participants at licensed clinics locations. This is a subsidized paid registry study. Patients will pay $12.99 a day for health fresh klotho favoring meals delivered to their home daily or can choose to shop themselves following recipes sent to save costs (will cut costs to about $5 to $7 per meal). If patients make their own meals they need to take a photo to upload to the study database daily. The BodStim™ EMS suit can be leased for 1 year with $890 down payment and monthly payments of $188. The 461 biomarker test is $800 each for non-members and $463 for members. The study sponsor Lionheart Health, Inc. will cover ALL muscle, brain and immunity health test assessments at baseline and 1 year. If patient selects to add voluntarily testing at 3 months and 6 months they will pay cost to cost for those extra tests. Optional AI enhanced MRI scans also will be covered by patients.

This study also supports Lionheart Health’s participation in XPRIZE Healthspan, where Lionheart Health Inc. was named a Top 40 Milestone 1 awardee semi-finalist from more than 600 registered teams worldwide, reflecting the strength of its proposed therapeutic approach, preliminary data and clinical testing strategy.

For more information about the Lionheart Klotho-Up™ Study, eligibility, participating sites, and informed consent requirements, contact Lionheart Health at Email Contact or visit Lionheart Longevity at https://www.LionheartLongevity.com to BOOK A VIDEO CONSULTATION with one of our trusted clinicians.

Contact
Lionheart Health, Inc.

https://www.LionheartLongevity.com

email: Email Contact

Important Notice: The Lionheart Klotho-Up™ Study is intended for research, wellness and health optimization purposes. Participation requires informed consent. Individual results may vary. Optional therapies are not available to all participants and may be subject to additional eligibility criteria, regulatory limitations, and separate consent requirements. This announcement is not intended as medical advice or as a claim of diagnosis, treatment, cure, or prevention of disease. Any early stage pilot clinical data communicated may not hold up in full scale statistically significant controlled studies.

Howard J. Leonhardt

Executive Chairman & co-CEO

Lionheart Health, Inc.

Leonhardt Ventures LLC

21060 Pacific City Cir 6115

Huntington Beach, CA 92648

R&D Lab 5270 California. Avenue, Irvine, CA 92617

Research Clinic and Training Center for Licensed Clinics

4440 Von Karman, Ste 100

Newport Beach, CA 92660

https://www.leonhardtventures.com

https://www.lionhearthealthstim.com