Researchers at Leonhardt Ventures Unveil E-Stent™ A Breakthrough Bioelectric Stimulation Stent Tech Platform

Leonhardt Ventures LLC today announced a major leap forward in regenerative medical technology with the introduction of E-Stent™, the first wireless, bioelectric protein-expression stent designed to activate or inhibit specific regenerative proteins directly from vessel walls and surrounding tissues.

Developed by the Leonhardt R&D engineering team in Irvine, led by CTO Brian Lasater and CEO Howard Leonhardt, the E-Stent™ system combines a next-generation implant with a wireless wearable harness that delivers controlled protein expressions (bioelectric signals) to micro-coils embedded along the stent. Stent sizes range from micro-implants smaller than a pea to 28 mm aortic stents, enabling applications across multiple organ systems.

"This is no longer a theory or a dream we have working prototypes in testing now which are controlling regenerative and healing protein expressions on demand enabled fully by wireless energy" stated Brian Lasater CTO of Leonhardt Ventures LLC and Lionheart Health, Inc.

Exclusive Licensing Across 29 Specialized Applications

Leonhardt Ventures LLC has granted exclusive licenses for the E-Stent™ platform to the following entities:

1. KidneyCell™ http://www.kidney-cell.com- for kidney regeneration
2. CerebraCell™ http://www.cerebracell.com- for brain health, stroke and TBI recovery, brain aneurysm treatment
3. AddictiStim™ http://www.addictistim.com- for addiction treatment
4. MemoryStim™ http://www.memory-stim.com- for memory improvement, dementia, and Alzheimer's treatment
5. DepressiStim™ http://www.depressistim.com- for severe depression and anxiety treatment
6. BioLeonhardt™ http://www.bioleonhardt.com- for heart regeneration
7. CancerCell™ http://www.cancercellinc.com- for cancer treatment
8. Ear-Cell™ http://www.ear-cell.com- for hearing regeneration
9. Eye-Cell™ http://www.eye-cell.com- for vision regeneration
10. Lionheart Health http://www.lionhearthealthstim.com- for healthspan longevity and medical aesthetics
11. Vascustim™ http://www.vascustim.com- for limb salvage, leg and foot wound healing, peripheral artery disease
12. AortaCell™ http://www.aortacell.com- for aorta regeneration, aortic aneurysm treatment
13. SpineStim™ http://www.spine-stim.com- for spinal cord injury recovery
14. BioPace™ http://www.bio-pace.com- for biological pacemaker regeneration
15. PressureStim™ http://www.pressurestim.com- for blood pressure control
16. InStim™ http://www.instimcell.com- for inflammation modulation and bowel or digestion disorders
17. LiverCell™ http://www.livercellstim.com- for liver regeneration
18. BladderCell™ http://www.bladdercell.com-for bladder dysfunction recovery
19. BreatheStim™ http://www.breathestim.com- for breathing and sleep optimization
20. ImplantStim™ http://www.implantstim.com- for dental implant healing
21. Second Brain™ http://www.secondbrainstim.com- for gut health optimization
22. Stem Cell Bra™ http://www.stemcellbra.com- for breast augmentation
23. SkinStim™ http://www.skin-stim.com- for skin regeneration
24. ErectiStim™ http://www.erectistim.comand FemStim™ - for sexual health
25. TestiStim™ http://www.testistim.com- for testosterone management
26. TremorStim™ http://www.tremorstim.com- for essential tremor treatment
27. PancreaCell™ https://vimeo.com/170533425?fl=pl&fe=sh- for pancreas regeneration and diabetes treatment
28. OrthoStim™ http://www.ortho-stim.com- for all orthopedic applications, including knee osteoarthritis, hip healing, and bone density
29. DentaCell™ http://www.dentacellaccelerator.com- for all dental applications

A New Frontier in Regenerative Medicine

Through selective bioelectric signaling, th E-Stent™ platform can stimulate or inhibit a broad range of proteins, including klotho, sestrins, sirtuins, apelin, LIM, CXCL5, tropoelastin, COL17A1, SDF1 (stem cell homing), PDGF, NANOG, RANK-L, BMP9, OPG, VEGF, S100a, HIF1a, BDNF, Sonic Hedgehog, TGFb, and FABp4 downregulation, and many others known to influence.

These stimulations can be directed to control stem cell homing, proliferation, and differentiation on demand, improving circulation, restoring muscle strength, modulating inflammation and blood pressure, improving nerve connections and viability, restoring elasticity, and more.

This platform represents a significant evolution of Leonhardt Ventures' previously announced KlothoImplant Bioelectric MicroImplant for controlling protein expressions on demand, KLOTHO, expanding the same core capabilities into advanced vascular implant formats.

The Lionheart Health (majority owned by Leonhardt Ventures LLC) team was recently recognized by Medtech Outlook Magazine as Micro Implant Stimulator Development of the Year 2025 https://www.medicaltechoutlook.com/lionheart-health-inc

Lionhert Health was also recently recognized as Abbvie Allergan ULP Innovation of the Year in Medical Aesthetics and as a top 40 semi-finalist in the $101 Million Xprize Healthspan competition out of 600 entries. Other recent distinctions include a 2025 finalist in both OCBJ Innovator of the Year and Octane Life Sciences Technology Co of the Year Awards.

For more information or interview requests, please email:  [email protected]

About Leonhardt Ventures LLC

Leonhardt Ventures www.leonhardtventure.com and its affiliated teams have been developing medical technologies since 1982. More than 600,000 patients worldwide have been treated with Leonhardt's inventions to date.

About Lionheart Health, Inc.

Lionheart Health is a 2022 spin out of Leonhardt Ventures LLC focused on the convergence of healthspan longevity and medical aesthetics - aging reversal inside and out. Primary business model is licensing clinics it's proprietary technology platform harnessing bioelectric stimulation to control regenerative protein expressions. The flagship development of this team is a whole body regeneation chamber "a womb for adults". They are recognied as the world leader in elevating circlating klotho levels, a tool for aging reversal and healthspan longevity, currently enrolling in clinical studies worldwide.

Leonhardt Ventures LLC

Office Headquarters

210101 Pacific City Cir 1406
Huntington Beach, CA 92648

R&D Lab

5270 California Avenue
Irvine, CA 92617

Lionheart Health, Inc.  |  Leonhardt Ventures LLC

Research Clinic and Training Center

4740 Von Karman, Ste 150
Newport Beach, CA 92660

http://www.leonhardtventures.com

http://www.lionhearthealthstim.com

http://www.lionheartlongevity.com

Disclaimer: Products are not fully proven yet to be safe or effective all are still in clinical studies.